Search results for " WEEKLY"
showing 6 items of 6 documents
Weekly Dose-Dense Cisplatin-Epirubicin-Paclitaxel Administration with Granulocyte Colony-Stimulating Factor Support Does Not Substantially Improve Pr…
2004
Purpose: The present study was aimed at defining the antitumor activity of the cisplatin-epirubicin-paclitaxel (PET) weekly administration with granulocyte colony-stimulating factor (G-CSF) support in chemonaive small-cell lung cancer patients with extensive disease (ED-SCLC). Methods: Chemonaive ED-SCLC patients received cisplatin 30 mg/sqm, epirubicin 50 mg/sqm and paclitaxel 120 mg/sqm, weekly, with G-CSF (5 μg/kg from day 3 to 5) support, for a maximum of 12 weeks. Results: Thirty-nine patients were treated, for a total of 354 cycles delivered. Eight complete (21%), and 22 partial responses (56%) were recorded, giving a 77% (95% Cl = 61-89%) objective response rate (ORR). After 14 (rang…
Quality of life in melanoma patients during adjuvant treatment with pegylated interferon-α2b: patients’ and doctors’ views
2011
Treatment of malignant melanoma with IFN-α has been associated with significant side-effects. The aim of this retrospective monocentric non-randomized study was first to evaluate the impact on quality of life (QOL) in 30 melanoma patients treated with once weekly 2 μg/kg PEG-IFN-α2b for 18 months, and second to examine whether there is a difference in patients' and physicians' perception of QOL. Data on QOL were collected by means of the EORTC QLQ-C30 questionnaire completed by the patient before consultation at baseline and every three months during treatment. A second questionnaire was filled out independently by the physician, based on the consultation and patient file. All data were rou…
Weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) as first-line chemotherapy for elderly patients with advanced gastric cancer: results of …
2006
Abstract Background Elderly patients have been often excluded from or underrepresented in the study populations of combination chemotherapy trials. The primary end point of this study was to determine the response rate and the toxicity of the weekly oxaliplatin, 5-fluorouracil and folinic acid (OXALF) regimen in elderly patients with advanced gastric cancer. The secondary objective was to measure the time to disease progression and the survival time. Methods Chemotherapy-naive patients with advanced gastric cancer aged 70 or older were considered eligible for study entry. Patients received weekly oxaliplatin 40 mg/m2, fluorouracil 500 mg/m2 and folinic acid 250 mg/m2. All drugs were given i…
Weekly docetaxel in the treatment of metastatic breast cancer
2008
Breast cancer is the most frequent tumor among women worldwide and is the second cause of cancer-related mortality in the US. Metastatic breast cancer (MBC) accounts for less than 10% of newly diagnosed breast cancer patients and about 30% of early breast cancer patients will develop recurrent, advanced, or metastatic disease. It remains an incurable illness and the primary goal of its management is palliative. Several agents are active for the fi rst-line treatment of MBC. The taxanes, paclitaxel and docetaxel, represent the standard of care for the treatment of these patients. Among the various schedules, docetaxel can be administered weekly, achieving similar effi cacy results with lower…
Satyra na Augusta Zaleskiego, czyli o sporze Wojciecha Wasiutyńskiego z "Syreną" paryską
2017
In 1949 the Parisian weekly Syrena published an anonymous satire on President August Zaleski. As it later turned out, it was written by Wojciech Wasiutyński, a well-known journalist and activist of the Stronnictwo Narodowe (National Party). Wasiutyński was not informed about the decision to publish his text and was outraged, demanding compensation. The editorial team explained that the anonymous copies of the satire had circulated among Polish immigrants. The issue echoed a far more significant debate concerning the office of the President of Poland in exile.
Hyväksymis- ja omistautumisterapian muutosprosessien merkitys masennuksen hoidossa : terapiaistuntojen välissä sovellettujen prosessien yhteys hoitot…
2013
Masennus on maailmanlaajuisesti yksi yleisimmistä toimintakykyä alentavista mielenterveyden häiriöistä. Yleisimmin sairautta hoidetaan lääkkeillä tai psykoterapialla ja useissa terapiasuuntauksissa kotitehtäviä käytetään hoitoa tukevana elementtinä. Kotitehtävien tavoitteena on siirtää terapiassa opittuja taitoja asiakkaan arkielämään. Hyväksymis- ja omistautumisterapia on osoittautunut tehokkaaksi hoitomuodoksi masennuksen hoidossa ja sen käyttö onkin yleistynyt viime vuosina. Hyväksymis- ja omistautumisterapian tavoitteena on asiakkaan psykologisen joustavuuden kasvattaminen, johon pyritään kuuden eri muutosprosessin avulla. Terapiassa käytetään paljon kotitehtäviä, jotka keskittyvät pros…